Christmas party 2024

08 December, 2024

New publication: The senescence-associated secretory phenotype and its physiological and pathological implications

01 December, 2024

Lab happy hour 2024

28 November, 2024

Welcome, Chi Zhang!

01 November, 2024

Welcome, Bertien Dethmers-Ausema!

14 October, 2024

Welcome, Francesca Pagliarin!

01 October, 2024

Welcome, Trupthi Joshi!

01 September, 2024

New publication: Sport and longevity an observational study of international athletes

12 August, 2024

ERIBA retreat 2024

11 July, 2024

Lab retreat 2024

22 June, 2024

New publication: Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury

01 June, 2024

New publication: The senescence-associated secretory phenotype and its physiological and pathological implications

23 April, 2024

New publication: In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes

01 April, 2024

New publication: One-step rapid tracking and isolation of senescent cells in cellular systems tissues or animal models via GLF16

15 March, 2024

Judith Campisi, PhD, FAACR: In Memoriam (1948–2024)

15 March, 2024

Welcome, Pilar Picallos-Rabina!

01 March, 2024

New publication: Change in telomere length and cardiovascular risk factors in testicular cancer survivors

01 January, 2024

New publication: Cellular senescence in brain aging and neurodegeneration

01 January, 2024

New publication: Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation

01 January, 2024

Welcome, Anton Stamm!

01 January, 2024

New publication: Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease

01 December, 2023

Welcome, Alessio Piccolantonio!

01 December, 2023

New publication: Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence

01 September, 2023

Lab retreat 2023

27 June, 2023

New publication: Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues

01 June, 2023

New publication: The effects of macronutrients metabolism on cellular and organismal aging

01 June, 2023

New publication: High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice

01 March, 2023

New publication: Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults

27 February, 2023

Welcome, Lotte Steeneken!

01 February, 2023

New publication: Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression

23 December, 2022

Welcome, Mengling Huang!

01 November, 2022

New publication: Senescence and cancer - role and therapeutic opportunities

01 October, 2022

Welcome, Sjors Maassen!

01 October, 2022

Jamil's defence 2022

19 September, 2022

Welcome, Martijn Rutten!

01 September, 2022

New publication: Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry

12 August, 2022

New publication: Prognostic implications of cellular senescence in resected non-small cell lung cancer

01 August, 2022

Welcome, Letícya-Simone Melo Dos Santos!

01 August, 2022

Welcome, Myrthe Klaver!

01 July, 2022

New publication: Biological functions of therapy-induced senescence in cancer

01 June, 2022

New publication: Cellular senescence

23 May, 2022

New publication: Pharmacological CDK46 inhibition reveals a p53-dependent senescent state with restricted toxicity

15 March, 2022

New publication: The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

28 February, 2022

New publication: Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 DR5 selective agonist

28 January, 2022

Welcome, Abdullah Altulea!

03 January, 2022

New publication: The Quest to Define and Target Cellular Senescence in Cancer

15 December, 2021

Congratulations to Sebastian

09 November, 2021

New publication: A novel transcriptomic-based classifier for senescent cancer cells

01 November, 2021

Welcome, Teodora Gheorghe!

01 November, 2021

Welcome, Chen Ge!

01 November, 2021

New publication: Identification of distinct and age-dependent p16High microglia subtypes

01 October, 2021

New publication: Hepatic stellate cell senescence in liver fibrosis Characteristics mechanisms and perspectives

01 October, 2021

Lab retreat, 2021

13 September, 2021

Lab retreat 2021

13 September, 2021

New publication: Algorithmic assessment of cellular senescence in experimental and clinical specimens

01 May, 2021

New publication: Author Correction MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

01 May, 2021

New publication: To breathe or not to breathe Understanding how oxygen sensing contributes to age-related phenotypes

01 May, 2021

New publication: Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging

01 April, 2021

Thijmen defended his PhD

19 February, 2021

New publication: Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations

15 January, 2021

Welcome, Yao Lin!

01 January, 2021

New publication: ARDD 2020 from aging mechanisms to interventions

30 December, 2020

New publication: Cellular senescence contributes to radiation-induced hyposalivation by affecting the stemprogenitor cell niche

14 October, 2020

New publication: Cellular senescence as a potential mediator of COVID-19 severity in the elderly

01 October, 2020

New publication: Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells

01 October, 2020

New publication: A Senescence-Centric View of Aging Implications for Longevity and Disease

01 October, 2020

New publication: Senescent Cells in Cancer Therapy Friends or Foes

01 October, 2020

Boshi successfully defended his thesis

09 September, 2020

Boshi's defence, 2020

09 September, 2020

Boshi's defence 2020

09 September, 2020

New publication: Cellular senescence impairs the reversibility of pulmonary arterial hypertension

29 July, 2020

New publication: Early ageing after cytotoxic treatment for testicular cancer and cellular senescence Time to act

01 July, 2020

Welcome, Sebastian Mackedenski!

15 February, 2020

New publication: A Bispecific Inhibitor of the EGFRADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells

10 February, 2020

Welcome, Marta Varela-Eirín!

01 November, 2019

New publication: Cellular Senescence Defining a Path Forward

31 October, 2019

New publication: SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells

24 September, 2019

New publication: Restored immune cell functions upon clearance of senescence in the irradiated splenic environment

01 August, 2019

New publication: Regulation of Survival Networks in Senescent Cells From Mechanisms to Interventions

12 July, 2019

New publication: Targeting senescent cells alleviates obesity-induced metabolic dysfunction

01 June, 2019

New publication: Systemic clearance of p16INK4a -positive senescent cells mitigates age-associated intervertebral disc degeneration

01 June, 2019

Lab retreat 2019

30 May, 2019

New publication: Identification of stable senescence-associated reference genes

01 April, 2019

Welcome, Willem Hoogaars!

01 February, 2019

Welcome, Michela Borghesan!

01 January, 2019

New publication: Caloric restriction and cellular senescence

01 December, 2018

Welcome, Eleni Fitsiou!

01 October, 2018

Lab retreat 2018

01 October, 2018

New publication: Induction and Validation of Cellular Senescence in Primary Human Cells

20 June, 2018

New publication: The effects of graded caloric restriction XII Comparison of mouse to human impact on cellular senescence in the colon

01 June, 2018

New publication: Hallmarks of Cellular Senescence

01 June, 2018

New publication: Gene therapy for p16-overexpressing cells

19 April, 2018

New publication: A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors

26 January, 2018

New publication: Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinsons Disease

23 January, 2018

New publication: Unmasking Transcriptional Heterogeneity in Senescent Cells

11 September, 2017

Welcome, Nynke Talma!

01 September, 2017

New publication: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

01 June, 2017

New publication: Therapeutic interventions for aging the case of cellular senescence

01 May, 2017

Welcome, Jamil Nehme!

01 May, 2017

Lab retreat 2017

11 March, 2017

New publication: Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

01 February, 2017

Welcome, Jaskaren Kohli!

01 January, 2017

Welcome, Abel Soto-Gamez!

01 October, 2016

Welcome, Thijmen van Vliet!

01 September, 2016

New publication: Cellular senescence and tumor promotion Is aging the key

01 April, 2016

Welcome, Boshi Wang!

01 February, 2016

Welcome, Alejandra Hernandez-Segura!

01 February, 2016

New publication: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

01 January, 2016

New publication: An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA

22 December, 2014

New publication: STAT3 Activities and Energy Metabolism Dangerous Liaisons

31 July, 2014

New publication: Environmental stress ageing and glial cell senescence a novel mechanistic link to Parkinsons disease

01 May, 2013

New publication: Matters of life and breath A role for hypoxia in determining cell state

01 August, 2012

New publication: Glucocorticoids suppress selected components of the senescence-associated secretory phenotype

01 August, 2012

New publication: STAT3 can serve as a hit in the process of malignant transformation of primary cells

01 August, 2012

New publication: From tissue invasion to glucose metabolism the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities

01 June, 2012

New publication: Lamin B1 loss is a senescence-associated biomarker

01 June, 2012

New publication: Hypoxia-inducible factor-1 and neuroglobin expression

18 April, 2012

New publication: Pro-malignant properties of STAT3 during chronic inflammation

01 April, 2012

New publication: A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction

01 November, 2010

New publication: Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

15 March, 2010