Lab publications

2024


Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury.
Nehme J, Mesilmany L, Varela-Eirin M, Brandenburg S, Altulea A, Lin Y, Gaya da Costa M, Seelen M, Hillebrands JL, van Goor H, Saab R, Akl H, Prevarskaya N, Farfariello V, Demaria M
Nat Aging
2024 June
Guidelines for minimal information on cellular senescence experimentation in vivo.
Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M
Cell
2024 August
The senescence-associated secretory phenotype and its physiological and pathological implications.
Wang B, Han J, Elisseeff JH, Demaria M
Nat Rev Mol Cell Biol
2024 April

2022


Senescence and cancer - role and therapeutic opportunities.
Schmitt CA, Wang B, Demaria M
Nat Rev Clin Oncol
2022 October
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity.
Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M
EMBO J
2022 March
Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.
Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg SM, Faller WJ, Ridky TW, Demaria M
Nat Commun
2022 December

2021


Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
van Vliet T, Varela-Eirin M, Wang B, Borghesan M, Brandenburg SM, Franzin R, Evangelou K, Seelen M, Gorgoulis V, Demaria M
Mol Cell
2021 May
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes.
van Vliet T, Casciaro F, Demaria M
Ageing Res Rev
2021 May
Algorithmic assessment of cellular senescence in experimental and clinical specimens.
Kohli J, Wang B, Brandenburg SM, Basisty N, Evangelou K, Varela-Eirin M, Campisi J, Schilling B, Gorgoulis V, Demaria M
Nat Protoc
2021 May

2020


Senescent Cells in Cancer Therapy: Friends or Foes?
Wang B, Kohli J, Demaria M
Trends Cancer
2020 October
A Senescence-Centric View of Aging: Implications for Longevity and Disease.
Borghesan M, Hoogaars WMH, Varela-Eirin M, Talma N, Demaria M
Trends Cell Biol
2020 October
Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells.
Casciaro F, Borghesan M, Beretti F, Zavatti M, Bertucci E, Follo MY, Maraldi T, Demaria M
Mech Ageing Dev
2020 October

2019


Cellular Senescence: Defining a Path Forward.
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M
Cell
2019 October

2018


Hallmarks of Cellular Senescence.
Hernandez-Segura A, Nehme J, Demaria M
Trends Cell Biol
2018 June
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.
Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M
Aging Cell
2018 June

2017


Unmasking Transcriptional Heterogeneity in Senescent Cells.
Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M
Curr Biol
2017 September
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH
Nat Med
2017 June
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J
Cancer Discov
2017 February

2016


Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D
Nat Med
2016 January

2014


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J
Dev Cell
2014 December

2024


Sport and longevity: an observational study of international athletes.
Altulea A, Rutten MGS, Verdijk LB, Demaria M
Geroscience
2024 Aug
Guidelines for minimal information on cellular senescence experimentation in vivo.
Ogrodnik M, Carlos Acosta J, Adams PD, d'Adda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Dürr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, von Zglinicki T, Yun MH, Grillari J, Demaria M
Cell
2024 Aug
Converting cell death into senescence by PARP1 inhibition improves recovery from acute oxidative injury.
Nehme J, Mesilmany L, Varela-Eirin M, Brandenburg S, Altulea A, Lin Y, Gaya da Costa M, Seelen M, Hillebrands JL, van Goor H, Saab R, Akl H, Prevarskaya N, Farfariello V, Demaria M
Nat Aging
2024 Jun
The senescence-associated secretory phenotype and its physiological and pathological implications.
Wang B, Han J, Elisseeff JH, Demaria M
Nat Rev Mol Cell Biol
2024 Apr
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.
Venz R, Goyala A, Soto-Gamez A, Yenice T, Demaria M, Ewald CY
Geroscience
2024 Apr
One-step rapid tracking and isolation of senescent cells in cellular systems, tissues, or animal models via GLF16.
Magkouta S, Veroutis D, Pousias A, Papaspyropoulos A, Giannetti K, Pippa N, Lougiakis N, Kambas K, Lagopati N, Polyzou A, Georgiou M, Chountoulesi M, Pispas S, Foutadakis S, Kyrodimos E, Pouli N, Marakos P, Kotsinas A, Verginis P, Valakos D, Vatsellas G, Petty R, Thanos D, Demaria M, Evangelou K, Di Micco R, Gorgoulis VG
STAR Protoc
2024 Mar
On the past, present and future of senotherapeutics.
Quarta M, Demaria M
NPJ Aging
2024 Feb
Change in telomere length and cardiovascular risk factors in testicular cancer survivors.
Volders ELD, Meijer C, Steeneken LS, Lubberts S, Zwart N, van Roon AM, Lefrandt JD, de Jong IJ, Demaria M, Nuver J, Gietema JA
Urol Oncol
2024 Jan
Cellular senescence in brain aging and neurodegeneration.
Melo Dos Santos LS, Trombetta-Lima M, Eggen B, Demaria M
Ageing Res Rev
2024 Jan
Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation.
Soto-Gamez A, van Es M, Hageman E, Serna-Salas SA, Moshage H, Demaria M, Pringle S, Coppes RP
Radiother Oncol
2024 Jan

2023


Circulating monocytes expressing senescence-associated features are enriched in COVID-19 patients with severe disease.
Lin Y, Postma DF, Steeneken LS, Melo Dos Santos LS, Kirkland JL, Espindola-Netto JM, Tchkonia T, Borghesan M, Bouma HR, Demaria M
Aging Cell
2023 Dec
A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells.
Magkouta S, Veroutis D, Pousias A, Papaspyropoulos A, Pippa N, Lougiakis N, Kambas K, Lagopati N, Polyzou A, Georgiou M, Chountoulesi M, Pispas S, Foutadakis S, Pouli N, Marakos P, Kotsinas A, Verginis P, Valakos D, Mizi A, Papantonis A, Vatsellas G, Galanos P, Bartek J, Petty R, Serrano M, Thanos D, Roussos C, Demaria M, Evangelou K, Gorgoulis VG
Mol Cell
2023 Oct
Decoding of translation-regulating entities reveals heterogeneous translation deficiency patterns in cellular senescence.
Papaspyropoulos A, Hazapis O, Altulea A, Polyzou A, Verginis P, Evangelou K, Fousteri M, Papantonis A, Demaria M, Gorgoulis V
Aging Cell
2023 Sep
Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues.
Linders AN, Dias IB, Ovchinnikova ES, Vermeer MCSC, Hoes MF, Markousis Mavrogenis G, Deiman FE, Arevalo Gomez KF, Bliley JM, Nehme J, Vink A, Gietema J, de Boer RA, Westenbrink D, Sillje HHW, Hilfiker-Kleiner D, van Laake LW, Feinberg AW, Demaria M, Bomer N, van der Meer P
JACC CardioOncol
2023 Jun
The effects of macronutrients metabolism on cellular and organismal aging.
Nehme J, Altulea A, Gheorghe T, Demaria M
Biomed J
2023 Jun
High dietary protein and fat contents exacerbate hepatic senescence and SASP in mice.
Nehme J, Yang D, Altulea A, Varela-Eirin M, Wang L, Hu S, Wu Y, Togo J, Niu C, Speakman JR, Demaria M
FEBS J
2023 Mar
Long-term intensive endurance exercise training is associated to reduced markers of cellular senescence in the colon mucosa of older adults.
Demaria M, Bertozzi B, Veronese N, Spelta F, Cava E, Tosti V, Piccio L, Early DS, Fontana L
NPJ Aging
2023 Feb
Cellular senescence and cardiovascular diseases: moving to the "heart" of the problem.
Evangelou K, Vasileiou PVS, Papaspyropoulos A, Hazapis O, Petty R, Demaria M, Gorgoulis VG
Physiol Rev
2023 Jan

2022


Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression.
Kohli J, Ge C, Fitsiou E, Doepner M, Brandenburg SM, Faller WJ, Ridky TW, Demaria M
Nat Commun
2022 Dec
Senescence and cancer - role and therapeutic opportunities.
Schmitt CA, Wang B, Demaria M
Nat Rev Clin Oncol
2022 Oct
Simple Detection of Unstained Live Senescent Cells with Imaging Flow Cytometry.
Malavolta M, Giacconi R, Piacenza F, Strizzi S, Cardelli M, Bigossi G, Marcozzi S, Tiano L, Marcheggiani F, Matacchione G, Giuliani A, Olivieri F, Crivellari I, Beltrami AP, Serra A, Demaria M, Provinciali M
Cells
2022 Aug
Prognostic implications of cellular senescence in resected non-small cell lung cancer.
Domen A, Deben C, De Pauw I, Hermans C, Lambrechts H, Verswyvel J, Siozopoulou V, Pauwels P, Demaria M, van de Wiel M, Janssens A, Hendriks JMH, Van Schil P, Vermorken JB, Vandamme T, Prenen H, Peeters M, Lardon F, Wouters A
Transl Lung Cancer Res
2022 Aug
Biological functions of therapy-induced senescence in cancer.
Fitsiou E, Soto-Gamez A, Demaria M
Semin Cancer Biol
2022 Jun
Cellular senescence.
Varela-Eirín M, Demaria M
Curr Biol
2022 May
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity.
Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M
EMBO J
2022 Mar
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions.
Secomandi L, Borghesan M, Velarde M, Demaria M
Hum Reprod Update
2022 Feb
Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist.
Soto-Gamez A, Wang Y, Zhou X, Seras L, Quax W, Demaria M
Cancer Lett
2022 Jan

2021


The Quest to Define and Target Cellular Senescence in Cancer.
Wang B, Demaria M
Cancer Res
2021 Dec
A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization.
Zampetidis CP, Galanos P, Angelopoulou A, Zhu Y, Polyzou A, Karamitros T, Kotsinas A, Lagopati N, Mourkioti I, Mirzazadeh R, Polyzos A, Garnerone S, Mizi A, Gusmao EG, Sofiadis K, Gál Z, Larsen DH, Pefani DE, Demaria M, Tsirigos A, Crosetto N, Maya-Mendoza A, Papaspyropoulos A, Evangelou K, Bartek J, Papantonis A, Gorgoulis VG
Mol Cell
2021 Dec
A novel transcriptomic-based classifier for senescent cancer cells.
Varughese FM, Demaria M
Trends Cancer
2021 Nov
Identification of distinct and age-dependent p16(High) microglia subtypes.
Talma N, Gerrits E, Wang B, Eggen BJL, Demaria M
Aging Cell
2021 Oct
Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives.
Zhang M, Serna-Salas S, Damba T, Borghesan M, Demaria M, Moshage H
Mech Ageing Dev
2021 Oct
Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis.
Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, Wiley S, Alimirah F, Kim DE, Payne T, Rosko A, Aimontche E, Deshpande SM, Neri F, Kuehnemann C, Demaria M, Ramanathan A, Campisi J
Cell Metab
2021 Jun
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
van Vliet T, Varela-Eirin M, Wang B, Borghesan M, Brandenburg SM, Franzin R, Evangelou K, Seelen M, Gorgoulis V, Demaria M
Mol Cell
2021 May
Algorithmic assessment of cellular senescence in experimental and clinical specimens.
Kohli J, Wang B, Brandenburg SM, Basisty N, Evangelou K, Varela-Eirin M, Campisi J, Schilling B, Gorgoulis V, Demaria M
Nat Protoc
2021 May
To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes.
van Vliet T, Casciaro F, Demaria M
Ageing Res Rev
2021 May
Author Correction: MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J
Nat Cell Biol
2021 May
The struggle of a good friend getting old: cellular senescence in viral responses and therapy.
Kohli J, Veenstra I, Demaria M
EMBO Rep
2021 Apr
Cellular Senescence and the Senescence-Associated Secretory Phenotype as Drivers of Skin Photoaging.
Fitsiou E, Pulido T, Campisi J, Alimirah F, Demaria M
J Invest Dermatol
2021 Apr
Unravelling Heterogeneity of Amplified Human Amniotic Fluid Stem Cells Sub-Populations.
Casciaro F, Zia S, Forcato M, Zavatti M, Beretti F, Bertucci E, Zattoni A, Reschiglian P, Alviano F, Bonsi L, Follo MY, Demaria M, Roda B, Maraldi T
Cells
2021 Jan
Binocular Integrated Visual Field Deficits Are Associated With Changes in Local Network Function in Primary Open-Angle Glaucoma: A Resting-State fMRI Study.
Demaria G, Invernizzi A, Ombelet D, Carvalho JC, Renken RJ, Cornelissen FW
Front Aging Neurosci
2021
Computational Methods for Continuous Eye-Tracking Perimetry Based on Spatio-Temporal Integration and a Deep Recurrent Neural Network.
Grillini A, Hernández-García A, Renken RJ, Demaria G, Cornelissen FW
Front Neurosci
2021

2020


ARDD 2020: from aging mechanisms to interventions.
Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon...
Aging (Albany NY)
2020 Dec
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.
Peng X, Wu Y, Brouwer U, van Vliet T, Wang B, Demaria M, Barazzuol L, Coppes RP
Cell Death Dis
2020 Oct
Cellular senescence as a potential mediator of COVID-19 severity in the elderly.
Nehme J, Borghesan M, Mackedenski S, Bird TG, Demaria M
Aging Cell
2020 Oct
Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells.
Casciaro F, Borghesan M, Beretti F, Zavatti M, Bertucci E, Follo MY, Maraldi T, Demaria M
Mech Ageing Dev
2020 Oct
A Senescence-Centric View of Aging: Implications for Longevity and Disease.
Borghesan M, Hoogaars WMH, Varela-Eirin M, Talma N, Demaria M
Trends Cell Biol
2020 Oct
Senescent Cells in Cancer Therapy: Friends or Foes?
Wang B, Kohli J, Demaria M
Trends Cancer
2020 Oct
Cellular Senescence Promotes Skin Carcinogenesis through p38MAPK and p44/42MAPK Signaling.
Alimirah F, Pulido T, Valdovinos A, Alptekin S, Chang E, Jones E, Diaz DA, Flores J, Velarde MC, Demaria M, Davalos AR, Wiley CD, Limbad C, Desprez PY, Campisi J
Cancer Res
2020 Sep
Cellular senescence impairs the reversibility of pulmonary arterial hypertension.
van der Feen DE, Bossers GPL, Hagdorn QAJ, Moonen JR, Kurakula K, Szulcek R, Chappell J, Vallania F, Donato M, Kok K, Kohli JS, Petersen AH, van Leusden T, Demaria M, Goumans MTH, De Boer RA, Khatri P, Rabinovitch M, Berger RMF, Bartelds B
Sci Transl Med
2020 Jul
The Human Touch: Using a Webcam to Autonomously Monitor Compliance During Visual Field Assessments.
Jones PR, Demaria G, Tigchelaar I, Asfaw DS, Edgar DF, Campbell P, Callaghan T, Crabb DP
Transl Vis Sci Technol
2020 Jul
Link between increased cellular senescence and extracellular matrix changes in COPD.
Woldhuis RR, de Vries M, Timens W, van den Berge M, Demaria M, Oliver BGG, Heijink IH, Brandsma CA
Am J Physiol Lung Cell Mol Physiol
2020 Jul
Early ageing after cytotoxic treatment for testicular cancer and cellular senescence: Time to act.
Lubberts S, Meijer C, Demaria M, Gietema JA
Crit Rev Oncol Hematol
2020 Jul
A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells.
Soto-Gamez A, Chen D, Nabuurs AGE, Quax WJ, Demaria M, Boersma YL
Cancers (Basel)
2020 Feb
Refinement and preliminary evaluation of two tablet-based tests of real-world visual function.
Jones PR, Tigchelaar I, Demaria G, Wilson I, Bi W, Taylor DJ, Crabb DP
Ophthalmic Physiol Opt
2020 Jan

2019


Cellular Senescence: Defining a Path Forward.
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer L, Passos JF, Robbins PD, Schmitt CA, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M
Cell
2019 Oct
SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells.
Wiley CD, Liu S, Limbad C, Zawadzka AM, Beck J, Demaria M, Artwood R, Alimirah F, Lopez-Dominguez JA, Kuehnemann C, Danielson SR, Basisty N, Kasler HG, Oron TR, Desprez PY, Mooney SD, Gibson BW, Schilling B, Campisi J, Kapahi P
Cell Rep
2019 Sep
Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.
Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C
Aging Cell
2019 Aug
Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.
Soto-Gamez A, Quax WJ, Demaria M
J Mol Biol
2019 Jul
Targeting senescent cells alleviates obesity-induced metabolic dysfunction.
Palmer AK, Xu M, Zhu Y, Pirtskhalava T, Weivoda MM, Hachfeld CM, Prata LG, van Dijk TH, Verkade E, Casaclang-Verzosa G, Johnson KO, Cubro H, Doornebal EJ, Ogrodnik M, Jurk D, Jensen MD, Chini EN, Miller JD, Matveyenko A, Stout MB, Schafer MJ, White TA, Hickson LJ, Demaria M, Garovic V, Grande J, Arriaga EA, Kuipers F, von Zglinicki T, LeBrasseur NK, Campisi J, Tchkonia T, Kirkland JL
Aging Cell
2019 Jun
Systemic clearance of p16(INK4a) -positive senescent cells mitigates age-associated intervertebral disc degeneration.
Patil P, Dong Q, Wang D, Chang J, Wiley C, Demaria M, Lee J, Kang J, Niedernhofer LJ, Robbins PD, Sowa G, Campisi J, Zhou D, Vo N
Aging Cell
2019 Jun
Identification of stable senescence-associated reference genes.
Hernandez-Segura A, Rubingh R, Demaria M
Aging Cell
2019 Apr
Cellular Senescence: Aging, Cancer, and Injury.
Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A
Physiol Rev
2019 Apr

2018


Caloric restriction and cellular senescence.
Fontana L, Nehme J, Demaria M
Mech Ageing Dev
2018 Dec
Induction and Validation of Cellular Senescence in Primary Human Cells.
Hernandez-Segura A, Brandenburg S, Demaria M
J Vis Exp
2018 Jun
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.
Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M
Aging Cell
2018 Jun
Hallmarks of Cellular Senescence.
Hernandez-Segura A, Nehme J, Demaria M
Trends Cell Biol
2018 Jun
Gene therapy for p16-overexpressing cells.
Demaria M
Aging (Albany NY)
2018 Apr
A novel suicide gene therapy for the treatment of p16(Ink4a)-overexpressing tumors.
Kohli J, Campisi J, Demaria M
Oncotarget
2018 Jan
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease.
Chinta SJ, Woods G, Demaria M, Rane A, Zou Y, McQuade A, Rajagopalan S, Limbad C, Madden DT, Campisi J, Andersen JK
Cell Rep
2018 Jan

2017


Unmasking Transcriptional Heterogeneity in Senescent Cells.
Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M
Curr Biol
2017 Sep
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH
Nat Med
2017 Jun
Therapeutic interventions for aging: the case of cellular senescence.
Soto-Gamez A, Demaria M
Drug Discov Today
2017 May
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J
Cancer Discov
2017 Feb
Senescent cells: New target for an old treatment?
Demaria M
Mol Cell Oncol
2017

2016


Cellular senescence and tumor promotion: Is aging the key?
Loaiza N, Demaria M
Biochim Biophys Acta
2016 Apr
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D
Nat Med
2016 Jan

2015


Simvastatin suppresses breast cancer cell proliferation induced by senescent cells.
Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P
Sci Rep
2015 Dec
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
Science
2015 Sep
Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.
Velarde MC, Demaria M, Melov S, Campisi J
Proc Natl Acad Sci U S A
2015 Aug
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J
Nat Cell Biol
2015 Aug
Cellular senescence and the aging brain.
Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK
Exp Gerontol
2015 Aug
Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin.
Demaria M, Desprez PY, Campisi J, Velarde MC
J Invest Dermatol
2015 Jul
p53 and rapamycin are additive.
Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P
Oncotarget
2015 Jun
Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
Neves J, Demaria M, Campisi J, Jasper H
Dev Cell
2015 Jan

2014


An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J
Dev Cell
2014 Dec
STAT3 and metabolism: how many ways to use a single molecule?
Demaria M, Camporeale A, Poli V
Int J Cancer
2014 Nov
STAT3 Activities and Energy Metabolism: Dangerous Liaisons.
Camporeale A, Demaria M, Monteleone E, Giorgi C, Wieckowski MR, Pinton P, Poli V
Cancers (Basel)
2014 Jul

2013


Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?
Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK
J Intern Med
2013 May
Senescent cells and their secretory phenotype as targets for cancer therapy.
Velarde MC, Demaria M, Campisi J
Interdiscip Top Gerontol
2013

2012


STAT3 can serve as a hit in the process of malignant transformation of primary cells.
Demaria M, Misale S, Giorgi C, Miano V, Camporeale A, Campisi J, Pinton P, Poli V
Cell Death Differ
2012 Aug
Matters of life and breath: A role for hypoxia in determining cell state.
Demaria M, Campisi J
Aging (Albany NY)
2012 Aug
Glucocorticoids suppress selected components of the senescence-associated secretory phenotype.
Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J
Aging Cell
2012 Aug
PKM2, STAT3 and HIF-1α: The Warburg's vicious circle.
Demaria M, Poli V
JAKSTAT
2012 Jul
From tissue invasion to glucose metabolism: the many aspects of signal transducer and activator of transcription 3 pro-oncogenic activities.
Pensa S, Demaria M, Avalle L, Barbieri I, Camporeale A, Poli V
Horm Mol Biol Clin Investig
2012 Jun
Lamin B1 loss is a senescence-associated biomarker.
Freund A, Laberge RM, Demaria M, Campisi J
Mol Biol Cell
2012 Jun
Hypoxia-inducible factor-1 and neuroglobin expression.
Haines B, Demaria M, Mao X, Xie L, Campisi J, Jin K, Greenberg DA
Neurosci Lett
2012 Apr
Pro-malignant properties of STAT3 during chronic inflammation.
Demaria M, Poli V
Oncotarget
2012 Apr

2011


From the nucleus to the mitochondria and back: the odyssey of a multitask STAT3.
Demaria M, Poli V
Cell Cycle
2011 Oct

2010


A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.
Demaria M, Giorgi C, Lebiedzinska M, Esposito G, D'Angeli L, Bartoli A, Gough DJ, Turkson J, Levy DE, Watson CJ, Wieckowski MR, Provero P, Pinton P, Poli V
Aging (Albany NY)
2010 Nov
Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten.
Barbieri I, Pensa S, Pannellini T, Quaglino E, Maritano D, Demaria M, Voster A, Turkson J, Cavallo F, Watson CJ, Provero P, Musiani P, Poli V
Cancer Res
2010 Mar