I was born and raised in a small agricultural town on the prairies of western Canada. I picked up a BSc and MSc in Biochemistry and Molecular Biology and spent a few years as a research associate studying KRAS-driven cancers of colorectal origin at the University of Northern British Columbia. Later, notwithstanding a couple great years in Vancouver at one of Canadaโs largest biotechnology companies, I decided to pursue my PhD at ERIBA to help further our understanding of cellular senescence in age-associated degenerative disease. In partnership with the Dutch Society for Research on Ageing, and the Vitality Oriented Innovations for the Life course of Aging Society (DuSRA-VOILA), my work focuses on cellular senescence in tissues that make up our musculoskeletal system.
Sebastian Mackedenski
โ MSc
PhD student
- Joined in February 2020
- From Canada ๐จ๐ฆ
non-coding RNA
Publications with the lab 3
Disruption of CDK4/6-RARฮฑ-NF-ฮบB axis attenuates senescence-associated inflammation and improves function during aging and following chemotherapy.
2026
Wang B,
Piccolantonio A,
Altulea A,
Huang M,
Joshi T,
Pagliarin F,
Di P,
Lin Y,
Mackedenski S,
Ustyantsev K,
Jager C,
Berezikov E,
Demaria M
Nat Aging
SenFlag gene signature identifies senescent cells in mouse and human tissues through a conserved core transcriptional program.
2026
Altulea A,
Mackedenski S,
Nehme J,
Demaria M
EMBO J
Cellular senescence as a potential mediator of COVID-19 severity in the elderly.
2020
Nehme J,
Borghesan M,
Mackedenski S,
Bird T,
Demaria M
Aging Cell