I come from China and I did my BSc study at Shanghai Jiao Tong University and my MPhil study at The University of Hong Kong. In September 2020, I received my PhD degree from the University of Groningen under the supervision of Prof. Marco Demaria. Now, I work as a Senior Researcher and mouse work coordinator in the Demaria lab. My research is mainly focused on three projects: 1) Exploring the roles of CDK4/6 inhibitors in senescence/SASP and cancer therapy; 2) Investigating the differential features of senescent cells from different sex origin; 3) Identifying the contribution of senescent cells to natural ageing; In my projects, patient biopsies, transgenic/xenograft mouse models, mammalian cell models, RNA-sequencing, proteomics, lipidomics and a series of biochemical methods are used.
Boshi Wang
● PhD
PostDoc
- Joined February 2016
- From China 🇨🇳
CDK4/6
sex disparity
natural aging
Publications with the lab 11
The senescence-associated secretory phenotype and its physiological and pathological implications.
2024
Wang B,
Han J,
Elisseeff J,
Demaria M
Nat Rev Mol Cell Biol
Senescence and cancer - role and therapeutic opportunities.
2022
Schmitt C,
Wang B,
Demaria M
Nat Rev Clin Oncol
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity.
2022
Wang B,
Varela-Eirin M,
Brandenburg S,
Hernandez-Segura A,
van V,
Jongbloed E,
Wilting S,
Ohtani N,
Jager A,
Demaria M
EMBO J
The Quest to Define and Target Cellular Senescence in Cancer.
2021
Wang B,
Demaria M
Cancer Res
Identification of distinct and age-dependent p16(High) microglia subtypes.
2021
Talma N,
Gerrits E,
Wang B,
Eggen B,
Demaria M
Aging Cell
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression.
2021
van V,
Varela-Eirin M,
Wang B,
Borghesan M,
Brandenburg S,
Franzin R,
Evangelou K,
Seelen M,
Gorgoulis V,
Demaria M
Mol Cell
Algorithmic assessment of cellular senescence in experimental and clinical specimens.
2021
Kohli J,
Wang B,
Brandenburg S,
Basisty N,
Evangelou K,
Varela-Eirin M,
Campisi J,
Schilling B,
Gorgoulis V,
Demaria M
Nat Protoc
Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem/progenitor cell niche.
2020
Peng X,
Wu Y,
Brouwer U,
van V,
Wang B,
Demaria M,
Barazzuol L,
Coppes R
Cell Death Dis
Senescent Cells in Cancer Therapy: Friends or Foes?
2020
Wang B,
Kohli J,
Demaria M
Trends Cancer
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon.
2018
Fontana L,
Mitchell S,
Wang B,
Tosti V,
van V,
Veronese N,
Bertozzi B,
Early D,
Maissan P,
Speakman J,
Demaria M
Aging Cell
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
2017
Demaria M,
O'Leary M,
Chang J,
Shao L,
Liu S,
Alimirah F,
Koenig K,
Le C,
Mitin N,
Deal A,
Alston S,
Academia E,
Kilmarx S,
Valdovinos A,
Wang B,
de B,
Kennedy B,
Melov S,
Zhou D,
Sharpless N,
Muss H,
Campisi J
Cancer Discov