I have B.Sc. in Biotechnology Engineering ITESM Monterrey Mexico / INSA Lyon France, and M.Sc. in Medical and Pharmaceutical Drug innovation, RUG, the Netherlands. In 2016 I started my PhD in the department of Chemical and Pharmaceutical Biology at the University of Groningen in collaboration with the European Research Institute for the Biology of Aging (ERIBA). In my project I specialized in protein-based senotherapeutics. I am currently working as a Post Doctoral researcher in Radiotherapy and Molecular Cell Biology in the Department of Biomedical Science of Cells & Systems at the UMCG, under the supervision of Profs. Drs. Rob Coppes, Sarah Pringe, and Marco Demaria. I am especially interested in the identification of exploitable pathways for the selective elimination of senescent cancer cells in the salivary gland and the use of novel approaches to modulate pro-inflammatory aspects of the senescence-associated secretory phenotype.
Abel Soto-Gamez
Lab alumni
- Spent 8 years in the lab, from October 2016 until September 2024
- From Mexico 🇲🇽
radiotherapy
Publications with the lab 7
In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes.
2024
Venz R,
Goyala A,
Soto-Gamez A,
Yenice T,
Demaria M,
Ewald C
Geroscience
Mesenchymal stem cell-derived HGF attenuates radiation-induced senescence in salivary glands via compensatory proliferation.
2024
Soto-Gamez A,
van E,
Hageman E,
Serna-Salas S,
Moshage H,
Demaria M,
Pringle S,
Coppes R
Radiother Oncol
Biological functions of therapy-induced senescence in cancer.
2022
Fitsiou E,
Soto-Gamez A,
Demaria M
Semin Cancer Biol
Enhanced extrinsic apoptosis of therapy-induced senescent cancer cells using a death receptor 5 (DR5) selective agonist.
2022
Soto-Gamez A,
Wang Y,
Zhou X,
Seras L,
Quax W,
Demaria M
Cancer Lett
A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells.
2020
Soto-Gamez A,
Chen D,
Nabuurs A,
Quax W,
Demaria M,
Boersma Y
Cancers (Basel)
Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions.
2019
Soto-Gamez A,
Quax W,
Demaria M
J Mol Biol
Therapeutic interventions for aging: the case of cellular senescence.
2017
Soto-Gamez A,
Demaria M
Drug Discov Today