Publications.
For a full list of publications click here.
Selected publications
Senescence and cancer - role and therapeutic opportunities
Schmitt C.A, Wang B, Demaria M. 2022. Nat Rev Clin Oncol.
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity
Wang B, Kohli J, Varela-Eirin M, Brandenburg S, Hernandez-Segura A, van Vliet T, Jongbloed E, Wilting S, Ohtani N, Jager A, Demaria M. 2022. EMBO J.
Algorithmic assessment of cellular senescence in experimental and clinical specimen
Kohli J, Wang B, Brandenburg S, Basisty N, Evangelou K, Varela Eirin M, Campisi J, Schilling B, Gorgoulis V, Demaria M. 2021. Nature Protocols
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
van Vliet T, Wang B, Varela-Eirin M, Borghesan M, Brandenburg S, Franzin R, Evangelou K, Seelen M, Gorgoulis V, Demaria M. 2021. Molecular Cell.
To breathe or not to breathe: understanding how oxygen sensing contributes to age-related phenotypes
van Vliet T, Casciaro F, Demaria M. 2020. Ageing Res. Rev.
A senescence-centric view of aging: Implications for longevity and disease.
Borghesan M*, Hoogaars WMH*, Varela Eirin M*, Talma N, Demaria M. 2020. Trends Cell Biol.
*equal contribution
Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells.
Casciaro F, Borghesan M, Beretti F, Zavatti M, Bertucci E, Follo MY, Maraldi T, Demaria M. 2020. Mech Ageing Dev.
Senescent cells in cancer therapy: friends or foes?
Wang B, Kohli J, Demaria M. 2020. Trends in Cancer.
A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells.
Soto-Gamez A, Chen D, Nabuurs AGE, Quax WJ, Demaria M, Boersma YL. 2020. Cancers (Basel).
Cellular senescence: defining a path forward.
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer N, Passos JF, Robbins PD, Schmitt C, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M. 2019. Cell.
Identification of stable senescence-associated reference genes.
Hernandez-Segura A, Rubingh R, Demaria M. 2019. Aging Cell.
Induction and Validation of Cellular Senescence in Primary Human Cells.
Hernandez-Segura A, Brandenburg S, Demaria M. 2018. JoVe.
The effects of graded caloric restriction: XIV. Comparison of mouse to human impact on cellular senescence in the colon.
Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M. 2018. Aging Cell.
Hallmarks of cellular senescence.
Hernandez-Segura A, Nehme J, Demaria M. 2018. Trends in Cell Biology.
A novel suicide gene therapy for the treatment of p16INK4a-overexpressing tumors.
Kohli J, Campisi J, Demaria M. 2018. Oncotarget.
Unmasking transcriptional heterogeneity of senescent cells.
Hernandez-Segura A, de Jong TV, Guryev V, Campisi J, Demaria M. 2017. Current Biology.
Local clearance of senescent cells prevents the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Jeon Oh, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot A, Chung JW, Kim DH, Poon Y, David N, Baker DJ, Van Deursen JM, Campisi J, Elisseeff JH. 2017. Nature Medicine.
Cellular senescence promotes adverse effects to chemotherapy and cancer relapse.
Demaria M#, O’Leary M, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia E, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H and Campisi J. 2017. Cancer Discovery. # corresponding author
Clearance of senescence cells by ABT263 rejuvenates aged hematopoietic stems cells in mice.
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Kragar K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. 2016. Nature Medicine.
Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.
Velarde M, Demaria M, Melov S, Campisi J. 2015. PNAS.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. 2014. . Developmental Cell.
Schmitt C.A, Wang B, Demaria M. 2022. Nat Rev Clin Oncol.
Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicity
Wang B, Kohli J, Varela-Eirin M, Brandenburg S, Hernandez-Segura A, van Vliet T, Jongbloed E, Wilting S, Ohtani N, Jager A, Demaria M. 2022. EMBO J.
Algorithmic assessment of cellular senescence in experimental and clinical specimen
Kohli J, Wang B, Brandenburg S, Basisty N, Evangelou K, Varela Eirin M, Campisi J, Schilling B, Gorgoulis V, Demaria M. 2021. Nature Protocols
Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression
van Vliet T, Wang B, Varela-Eirin M, Borghesan M, Brandenburg S, Franzin R, Evangelou K, Seelen M, Gorgoulis V, Demaria M. 2021. Molecular Cell.
To breathe or not to breathe: understanding how oxygen sensing contributes to age-related phenotypes
van Vliet T, Casciaro F, Demaria M. 2020. Ageing Res. Rev.
A senescence-centric view of aging: Implications for longevity and disease.
Borghesan M*, Hoogaars WMH*, Varela Eirin M*, Talma N, Demaria M. 2020. Trends Cell Biol.
*equal contribution
Prolonged hypoxia delays aging and preserves functionality of human amniotic fluid stem cells.
Casciaro F, Borghesan M, Beretti F, Zavatti M, Bertucci E, Follo MY, Maraldi T, Demaria M. 2020. Mech Ageing Dev.
Senescent cells in cancer therapy: friends or foes?
Wang B, Kohli J, Demaria M. 2020. Trends in Cancer.
A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells.
Soto-Gamez A, Chen D, Nabuurs AGE, Quax WJ, Demaria M, Boersma YL. 2020. Cancers (Basel).
Cellular senescence: defining a path forward.
Gorgoulis V, Adams PD, Alimonti A, Bennett DC, Bischof O, Bishop C, Campisi J, Collado M, Evangelou K, Ferbeyre G, Gil J, Hara E, Krizhanovsky V, Jurk D, Maier AB, Narita M, Niedernhofer N, Passos JF, Robbins PD, Schmitt C, Sedivy J, Vougas K, von Zglinicki T, Zhou D, Serrano M, Demaria M. 2019. Cell.
Identification of stable senescence-associated reference genes.
Hernandez-Segura A, Rubingh R, Demaria M. 2019. Aging Cell.
Induction and Validation of Cellular Senescence in Primary Human Cells.
Hernandez-Segura A, Brandenburg S, Demaria M. 2018. JoVe.
The effects of graded caloric restriction: XIV. Comparison of mouse to human impact on cellular senescence in the colon.
Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M. 2018. Aging Cell.
Hallmarks of cellular senescence.
Hernandez-Segura A, Nehme J, Demaria M. 2018. Trends in Cell Biology.
A novel suicide gene therapy for the treatment of p16INK4a-overexpressing tumors.
Kohli J, Campisi J, Demaria M. 2018. Oncotarget.
Unmasking transcriptional heterogeneity of senescent cells.
Hernandez-Segura A, de Jong TV, Guryev V, Campisi J, Demaria M. 2017. Current Biology.
Local clearance of senescent cells prevents the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Jeon Oh, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot A, Chung JW, Kim DH, Poon Y, David N, Baker DJ, Van Deursen JM, Campisi J, Elisseeff JH. 2017. Nature Medicine.
Cellular senescence promotes adverse effects to chemotherapy and cancer relapse.
Demaria M#, O’Leary M, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia E, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H and Campisi J. 2017. Cancer Discovery. # corresponding author
Clearance of senescence cells by ABT263 rejuvenates aged hematopoietic stems cells in mice.
Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Kragar K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. 2016. Nature Medicine.
Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells.
Velarde M, Demaria M, Melov S, Campisi J. 2015. PNAS.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé M, Hoeijmakers J, deBruin A, Hara E, Campisi J. 2014. . Developmental Cell.
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